CAS No.: | 62571-86-2 |
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Formula: | C9h15no3s |
EINECS: | 263-607-1 |
Color: | White |
Appearance: | Powder |
Name: | Captopril |
Samples: |
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Customization: |
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Quantity(bags) | 1 - 3000 | 3001 - 5000 | >5000 |
Lead time (days) | 10 | 20 | To be negotiated |
product name: | captopril |
Specification | 99% |
Exterior: | White powder |
Shelf life: | 2 years |
CAS: | 62571-86-2 |
Captopril, 1-[(2S)-3-mercapto-2-methyl-1-oxopropionyl]proline (Capoten), blocks the conversion of angiotensinI to angiotensin II by inhibiting the convertingenzyme. The rational development of captopril as an inhibitorof ACE was based on the hypothesis that ACE and carboxypeptidaseA functioned by similar mechanisms. It wasnoted that d-2-benzylsuccinic acid was a potent inhibitor ofcarboxypeptidase A, but not ACE. By use of this small molecule as a prototype, captopril was designed with a carboxylgroup on a proline and a thiol group was introduced toenhance the binding to the zinc ion of ACE. The importantbinding points at the active site of ACE are thought to be anarginine residue, which provides a cationic site that attracts acarboxylate ion, and a zinc ion, which can polarize a carbonylgroup of an amide function to make it more susceptible to hydrolysis.Hydrophobic pockets lie between these groups in theactive site, as does a functional group that forms a hydrogenbond with an amide carbonyl.
Application
1.Can be used as anti- hypertension medicament.
2. Captopril is used to control high blood pressure , relive symptoms of congestive heart failure , treat diabetic nephropathy
and also can be used to improve survival & decrease the chances of developing symptoms of congestive heart failure .
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5.Material: Owning cultivation based as 100% Natural material stable source.
6.Testing equipment:UV, HPLC, GC
7.Supply Ability:Production capacity: 300ton/year, large stock available;
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